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Drugs That Prolong the QT Interval and/or Induce Torsades de Pointes

-Raymond L. Woosley, MD, PhD

Information from the medical literature, the FDA-approved drug labeling and reports submitted to the FDA Adverse Events Reporting System database.

Browse by clicking on the first letter of the drug's brand or generic name:

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Generic Name Quetiapine PubMed Search
Brand Name(s) Seroquel®
Drug Class Anti-psychotic
QT
QT prolongation is mentioned in the FDA-approved labeling as a known action of the drug.
TdP
Risk Group A drug that may prolong the QT interval but at this time lacks substantial evidence for causing Torsades de Pointes. This drug should be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments

Generic Name Quinidine PubMed Search
Brand Name(s) Cardioquin® ,Quinaglute®
Drug Class Anti-arrhythmic
QT
QT prolongation is mentioned in the FDA-approved labeling as a known action of the drug.
TdP
The FDA-approved labeling includes mention of cases or a risk of Torsades de Pointes.
Risk Group A drug that is generally accepted by authorities to have a risk of causing Torsades de Pointes. This drug should be avoided for use in patients with diagnosed or suspected Congenital Long QT Syndrome.
Comments
Substantial evidence indicates a greater risk of Torsades de Pointes in women.
Females>Males

A note about Brand Names: Drugs are listed with up to 2 common brand names. There are many more brand names for some of the common drugs, such as pseudoephedrine and erythromycin. It is also important to look at the list of active drugs in medicines that contain a combination of drugs such as Zyrtec-D®, which contains pseudoephedrine.


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