| Class/Clinical
Use |
Comments |
||
| Albuterol | Ventolin® | Bronchodilator / Asthma | |
| Albuterol | Proventil® | Bronchodilator / Asthma | |
| Alfuzosin | Uroxatral® | Alpha1-blocker / Benign prostatic hyperplasia | |
| Amantadine | Symmetrel® | Dopaminergic/Anti-viral / Anti-infective/ Parkinson's Disease | |
| Amiodarone | Pacerone® | Anti-arrhythmic / abnormal heart rhythm | Females>Males,TdP risk regarded as low |
| Amiodarone | Cordarone® | Anti-arrhythmic / abnormal heart rhythm | Females>Males,TdP risk regarded as low |
| Amitriptyline | Elavil® | Tricyclic Antidepressant / depression | |
| Amphetamine | Dexedrine® | CNS stimulant / ADHD | This includes dextroamphetamine and amphetamine / dextroamphetamine combinations. |
| Amphetamine | Adderall® | CNS stimulant / ADHD | This includes dextroamphetamine and amphetamine / dextroamphetamine combinations. |
| Arsenic trioxide | Trisenox® | Anti-cancer / Leukemia | |
| Astemizole | Hismanal® | Antihistamine / Allergic rhinitis | No Longer available in U.S. |
| Atazanavir | Reyataz® | Protease inhibitor / HIV | |
| Atomoxetine | Strattera® | norepinephrine reuptake inhibitor / ADHD | |
| Azithromycin | Zithromax® | Antibiotic / bacterial infection | |
| Bepridil | Vascor® | Anti-anginal / heart pain | Females>Males |
| Chloral hydrate | Noctec® | Sedative / sedation/ insomnia | |
| Chloroquine | Aralen® | Anti-malarial / malaria infection | |
| Chlorpromazine | Thorazine® | Anti-psychotic/ Anti-emetic / schizophrenia/ nausea | |
| Ciprofloxacin | Cipro® | Antibiotic / bacterial infection | |
| Cisapride | Propulsid® | GI stimulant / heartburn | Restricted availability; Females>Males. |
| Citalopram | Celexa® | Anti-depressant / depression | |
| Clarithromycin | Biaxin® | Antibiotic / bacterial infection | |
| Clomipramine | Anafranil® | Tricyclic Antidepressant / depression | |
| Clozapine | Clozaril® | Anti-psychotic / schizophrenia | |
| Cocaine | Cocaine | Local anesthetic / | |
| Desipramine | Pertofrane® | Tricyclic Antidepressant / depression | |
| Dexmethylphenidate | Focalin® | CNS stimulant / ADHD | |
| Diphenhydramine | Benadryl® | Antihistamine / Allergic rhinitis, insomnia | |
| Diphenhydramine | Nytol® | Antihistamine / Allergic rhinitis, insomnia | |
| Disopyramide | Norpace® | Anti-arrhythmic / abnormal heart rhythm | Females>Males |
| Dobutamine | Dobutrex® | Catecholamine / heart failure and shock | |
| Dofetilide | Tikosyn® | Anti-arrhythmic / abnormal heart rhythm | |
| Dolasetron | Anzemet® | Anti-nausea / nausea, vomiting | |
| Domperidone | Motilium® | Anti-nausea / nausea | Not available in the U.S. |
| Dopamine | Intropine® | Inotropic agent / heart failure; hypotension; shock | |
| Doxepin | Sinequan® | Tricyclic Antidepressant / depression | |
| Dronedarone | Multaq® | Anti-arrhythmic / Atrial Fibrillation | |
| Droperidol | Inapsine® | Sedative;Anti-nausea / anesthesia adjunct, nausea | |
| Ephedrine | Rynatuss® | Bronchodilator, decongestant / Allergies, sinusitis, asthma | |
| Ephedrine | Broncholate® | Bronchodilator, decongestant / Allergies, sinusitis, asthma | |
| Epinephrine | Bronkaid® | catecholamine, vasoconstrictor / anaphylaxis, allergic reactions | |
| Epinephrine | Primatene® | catecholamine, vasoconstrictor / anaphylaxis, allergic reactions | |
| Erythromycin | Erythrocin® | Antibiotic;GI stimulant / bacterial infection; increase GI motility | Females>Males |
| Erythromycin | E.E.S.® | Antibiotic;GI stimulant / bacterial infection; increase GI motility | Females>Males |
| Felbamate | Felbatrol® | Anti-convulsant / seizure | |
| Fenfluramine | Pondimin® | Appetite suppressant / dieting, weight loss | |
| Flecainide | Tambocor® | Anti-arrhythmic / abnormal heart rhythm | |
| Fluconazole | Diflucan® | Anti-fungal / fungal infection | |
| Fluoxetine | Prozac® | Anti-depressant / depression | |
| Fluoxetine | Sarafem® | Anti-depressant / depression | |
| Foscarnet | Foscavir® | Anti-viral / HIV infection | |
| Fosphenytoin | Cerebyx® | Anti-convulsant / seizure | |
| Galantamine | Reminyl® | Cholinesterase inhibitor / Dementia, Alzheimer's | |
| Gatifloxacin | Tequin® | Antibiotic / bacterial infection | |
| Gemifloxacin | Factive® | Antibiotic / bacterial infection | |
| Granisetron | Kytril® | Anti-nausea / nausea and vomiting | |
| Halofantrine | Halfan® | Anti-malarial / malaria infection | Females>Males |
| Haloperidol | Haldol® | Anti-psychotic / schizophrenia, agitation | When given intravenously or at higher-than- recommended doses, risk of sudden death, QT prolongation and torsades increases. |
| Ibutilide | Corvert® | Anti-arrhythmic / abnormal heart rhythm | Females>Males |
| Imipramine | Norfranil® | Tricyclic Antidepressant / depression | |
| Indapamide | Lozol® | Diuretic / stimulate urine & salt loss | |
| Isoproterenol | Medihaler-Iso® | Catecholamine / allergic reaction | |
| Isoproterenol | Isupres® | Catecholamine / allergic reaction | |
| Isradipine | Dynacirc® | Anti-hypertensive / high blood pressure | |
| Itraconazole | Sporanox® | Anti-fungal / fungal infection | |
| Ketoconazole | Nizoral® | Anti-fungal / fungal infection | |
| Lapatinib | Tykerb® | Anti-cancer / breast cancer, metastatic | |
| Lapatinib | Tyverb® | Anti-cancer / breast cancer, metastatic | |
| Levalbuterol | Xopenex® | Bronchodilator / asthma | |
| Levofloxacin | Levaquin® | Antibiotic / bacterial infection | |
| Levomethadyl | Orlaam® | Opiate agonist / pain control, narcotic dependence | |
| Lisdexamfetamine | Vyvanse® | CNS stimulant / ADHD | |
| Lithium | Lithobid® | Anti-mania / bipolar disorder | |
| Lithium | Eskalith® | Anti-mania / bipolar disorder | |
| Mesoridazine | Serentil® | Anti-psychotic / schizophrenia | |
| Metaproterenol | Metaprel® | Bronchodilator / asthma | |
| Metaproterenol | Alupent® | Bronchodilator / asthma | |
| Methadone | Methadose® | Opiate agonist / pain control, narcotic dependence | Females>Males |
| Methadone | Dolophine® | Opiate agonist / pain control, narcotic dependence | Females>Males |
| Methylphenidate | Ritalin® | CNS stimulant / ADHD | |
| Methylphenidate | Concerta® | CNS stimulant / ADHD | |
| Mexiletine | Mexitil® | Anti-arrhythmic / Abnormal heart rhythm | |
| Midodrine | ProAmatine® | Vasoconstrictor / low blood pressure, fainting | |
| Moexipril/HCTZ | Uniretic® | Anti-hypertensive / high blood pressure | |
| Moxifloxacin | Avelox® | Antibiotic / bacterial infection | |
| Nicardipine | Cardene® | Anti-hypertensive / high blood pressure | |
| Nilotinib | Tasigna® | Anti-cancer / Leukemia | |
| Norepinephrine | Levophed® | Vasconstrictor, Inotrope / shock, low blood pressure | |
| Nortriptyline | Pamelor® | Tricyclic Antidepressant / depression | |
| Octreotide | Sandostatin® | Endocrine / acromegaly, carcinoid diarrhea | |
| Ofloxacin | Floxin® | Antibiotic / bacterial infection | |
| Ondansetron | Zofran® | Anti-emetic / nausea and vomiting | |
| Oxytocin | Pitocin® | Oxytocic / Labor stimulation | |
| Paliperidone | Invega® | Antipsychotic, atypical / Schizophrenia | |
| Paroxetine | Paxil® | Anti-depressant / depression | |
| Pentamidine | NebuPent® | Anti-infective / pneumocystis pneumonia | Females>Males |
| Pentamidine | Pentam® | Anti-infective / pneumocystis pneumonia | Females>Males |
| Perflutren lipid microspheres | Definity® | Imaging contrast agent / Echocardiography | |
| Phentermine | Fastin® | Appetite suppressant / dieting, weight loss | |
| Phentermine | Adipex® | Appetite suppressant / dieting, weight loss | |
| Phenylephrine | Neosynephrine® | Vasoconstrictor, decongestant / low blood pressure, allergies, sinusitis, asthma | |
| Phenylpropanolamine | Dexatrim® | Decongestant / allergies, sinusitis, asthma | |
| Phenylpropanolamine | Acutrim® | Decongestant / allergies, sinusitis, asthma | |
| Pimozide | Orap® | Anti-psychotic / Tourette's tics | Females>Males |
| Probucol | Lorelco® | Antilipemic / Hypercholesterolemia | No longer available in U.S. |
| Procainamide | Pronestyl® | Anti-arrhythmic / abnormal heart rhythm | |
| Procainamide | Procan® | Anti-arrhythmic / abnormal heart rhythm | |
| Protriptyline | Vivactil® | Tricyclic Antidepressant / depression | |
| Pseudoephedrine | PediaCare® | Decongestant / allergies, sinusitis, asthma | |
| Pseudoephedrine | Sudafed® | Decongestant / allergies, sinusitis, asthma | |
| Quetiapine | Seroquel® | Anti-psychotic / schizophrenia | |
| Quinidine | Quinaglute® | Anti-arrhythmic / abnormal heart rhythm | Females>Males |
| Quinidine | Cardioquin® | Anti-arrhythmic / abnormal heart rhythm | Females>Males |
| Ranolazine | Ranexa® | Anti-anginal / chronic angina | |
| Risperidone | Risperdal® | Anti-psychotic / schizophrenia | |
| Ritodrine | Yutopar® | Uterine relaxant / prevent premature labor | |
| Ritonavir | Norvir® | Protease inhibitor / HIV | |
| Roxithromycin* | Rulide® | Antibiotic / bacterial infection | *not available in the United States |
| Salmeterol | Serevent® | Sympathomimetic / asthma, COPD | |
| Sertindole | Serlect® | Antipsychotic, atypical / Anxiety, Schizophrenia | |
| Sertindole | Serdolect® | Antipsychotic, atypical / Anxiety, Schizophrenia | |
| Sertraline | Zoloft® | Anti-depressant / depression | |
| Sibutramine | Meridia® | Appetitie suppressant / dieting, weight loss | |
| Solifenacin | VESIcare® | muscarinic receptor anatagonist / treatment of overactive bladder | |
| Sotalol | Betapace® | Anti-arrhythmic / abnormal heart rhythm | Females>Males |
| Sparfloxacin | Zagam® | Antibiotic / bacterial infection | |
| Sunitinib | Sutent® | Anti-cancer / RCC, GIST | |
| Tacrolimus | Prograf® | Immunosuppressant / Immune suppression | |
| Tamoxifen | Nolvadex® | Anti-cancer / breast cancer | |
| Telithromycin | Ketek® | Antibiotic / bacterial infection | |
| Terbutaline | Brethine® | Bronchodilator / asthma | |
| Terfenadine | Seldane® | Antihistamine / Allergic rhinitis | No longer available in U.S. |
| Thioridazine | Mellaril® | Anti-psychotic / schizophrenia | |
| Tizanidine | Zanaflex® | Muscle relaxant / | |
| Tolterodine | Detrol® | Bladder Antispasmodic / | |
| Tolterodine | Detrol LA® | Bladder Antispasmodic / | |
| Trazodone | Desyrel® | Anti-depressant / Depression, insomnia | |
| Trimethoprim-Sulfa | Sulfa® | Antibiotic / bacterial infection | |
| Trimethoprim-Sulfa | Bactrim® | Antibiotic / bacterial infection | |
| Trimipramine | Surmontil® | Tricyclic Antidepressant / depression | |
| Vardenafil | Levitra® | phosphodiesterase inhibitor / vasodilator | |
| Venlafaxine | Effexor® | Anti-depressant / depression | |
| Voriconazole | VFend® | Anti-fungal / anti-fungal | |
| Ziprasidone | Geodon® | Anti-psychotic / schizophrenia |
Revised: 03/30/2010
Source: www.QTdrugs.org
Drugs on the QT Drug Lists are reviewed on an ongoing basis to assure the evidence is still appropriate for their placement on their respective list.
KEY
Drugs to be Avoided |
Drugs to be avoided for use in patients with diagnosed or suspected congenital long QT syndrome. (Drugs on our category- of-risk lists are also included here, as are some additional drugs.) |
Females > Males: |
Substantial evidence indicates a greater risk (usually > two-fold) of TdP in women. |
Arizona Center for Education and Research on Therapeutics
The Critical Path Institute
Tucson, Arizona and Rockville, Maryland
Funded in part by Agency for Healthcare Research and Quality grant 1 U18 HS10385
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