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Medications that Interact with Methadone

One of our research interests is the safety of methadone prescribed in community settings. Many people taking prescribed methadone also take other medications. Consumers may not always be aware that combining methadone with other medications (including prescribed and non-prescribed drugs) can alter the effects of the drugs or result in adverse drug events.

Patients taking methadone and any other medicine should talk with their doctor or pharmacist about their medications. Patients should know that not all people will experience adverse events when taking other medications with methadone, and that there may be times when their doctor will need to prescribe other medicines along with methadone.

Medline Plus, a service of the U.S. National Library of Medicine and the National Institutes of Health, offers more information on drug safety.

FDA Information for Health Professionals


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